Protein Sequence Databases

Protein databases are more specialized than primary sequence databases. They contain information derived from the primary sequence databases. Some contain protein translations of the nucleic acid sequences. Some contain sets of patterns and motifs derived from sequence homologs. 

UniProtKB UniProt Knowledgebase is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation. About 85 % of the protein sequences provided by UniProtKB are derived from the translation of the coding sequences (CDS) which have been submitted to the public nucleic acid databases, the EMBL-Bank/GenBank/DDBJ databases (INSDC). All these sequences, as well as the related data submitted by the authors, are automatically integrated into UniProtKB/TrEMBL

 

SWISS-PROT & TrEMBL - SWISS-PROT is a curated protein sequence database. is a computer-annotated supplement of SWISS-PROT that contains all the translations of EMBL nucleotide sequence entries not yet integrated in SWISS-PROT.

 

PIR Protein Information Resource -a comprehensive, non-redundant, expertly annotated, fully classified and extensively cross-referenced protein sequence database.

PIR-PSD: PIR-International Protein Sequence Database (PIR-PSD), the world's first database of classified and functionally annotated protein sequences that grew out of the Atlas of Protein Sequence and Structure. PIR-PSD has been the most comprehensive and expertly-curated protein sequence database in the public domain for over 20 years. In 2002, PIR joined EBI (European Bioinformatics Institute) and SIB (Swiss Institute of Bioinformatics) to form the UniProt consortium. PIR-PSD sequences and annotations have been integrated into UniProt Knowledgebase. Bi-directional cross-references between UniProt (UniProt Knowledgebase and/or UniParc) and PIR-PSD are established to allow easy tracking of former PIR-PSD entries. PIR-PSD unique sequences, reference citations, and experimentally-verified data can now be found in the relevant UniProt records.